Effect of C'1 esterase on vascular permeability in man: studies in normal and complement-deficient individuals and in patients with hereditary angioneurotic edema.

Permeability-increasing activity in hereditary angioneurotic edema plasma. II. Mechanism of formation and partial characterization.

Plasma from persons with hereditary angioneurotic edema readily developed the capacity to increase vascular permeability and to induce the isolated rat uterus to contract. Both activities resided in a small, heat-stable molecule that was apparently a polypeptide. Crude preparations of the polypeptide were inactivated during incubation with trypsin. They also failed to produce pain and erythema,...

Mechanisms of Activation of C'1 Esterase in Hereditary Angioneurotic Edema Plasma in Vitro

The generation of C'1 esterase activity in siliconed plasma obtained from individuals with hereditary angioneurotic edema in remission tends to occur spontaneously, but can be hastened during its incubation with preparations of activated Hageman factor. This effect of activated Hageman factor could not be shown during its incubation with normal siliconed plasma, nor could consumption of normal ...

Angioedema Induced by a Peptide Derived from Complement Component

Several lines of experimental evidence have suggested that one or more peptides that can enhance vascular permeability may be released from the second component ofhuman complement, C2 (1-5) . This possibility is important to understanding the molecular mechanisms that lead to bouts of circumscribed edema to which persons with hereditary angioneurotic edema (HANE)' are susceptible. Persons with ...

Human Plasma Alpha 2-macroglobulin

Activation of plasma kallikrein arginine esterase activity by kaolin resulted in peak activity at 1 min of incubation and a 50% reduction in activity at 5 min in normal plasma, and 30% reduction in the plasma of patients with hereditary angioneurotic edema who lacked the C1 inactivator. The peak esterolytic activity was inhibited by soybean trypsin inhibitor whereas the 5 min activity was resis...

Action of Complement in Hereditary Angioneurotic Edema: the Role of C'1-esterase.